解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Occurrence, elicitors and treatment of severe allergic reactions are recognized and reported differently between countries. We aimed to collect standardized data throughout Europe on anaphylaxis referred for diagnosis and counselling. METHODS:Tertiary allergy, dermatology and paediatric units in 10 European...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12475
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Allergy to atracurium is a rare condition with serious consequences of diagnostic error. However, correct diagnosis is not always straightforward. The aim of this study is to assess the utility of the basophil activation test (BAT) in atracurium sensitization and to investigate its role in identifying cross-...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12468
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Associations between vitamin D status and childhood asthma are increasingly reported, but direct causation and mechanisms underlying an effect remain unknown. We investigated the effect of early-life vitamin D deficiency on the development of murine neonatal allergic airways disease (AAD). METHODS:In utero ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12465
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Although asthma is characterized by variable airways obstruction, most studies of asthma phenotypes are cross-sectional. The stability of phenotypes defined either by biomarkers or by physiological variables was assessed by repeated measures over 1 year in the Pan-European BIOAIR cohort of adult asthmatics. ...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/all.12445
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Genomewide association and epigenetic studies found a region within the RAD50 gene on chromosome 5q31 to be associated with total serum IgE levels and asthma. In mice, this region harbors a locus control region for nearby TH 2 cytokines, which is characterized by four Rad50 DNase I hypersensitive sites (RHS4...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12450
更新日期:2014-09-01 00:00:00
abstract::There are studies demonstrating that skin-test sensitivity to penicillins can decrease over time and that allergic patients may lose sensitivity if the responsible compounds are avoided. With regard to subjects with IgE-mediated hypersensitivity to cephalosporins, however, such studies are lacking. We evaluated prospe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12390
更新日期:2014-06-01 00:00:00
abstract::This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mi...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12378
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is an inflammatory process in the nasal cavity and paranasal sinuses, and bacteria have been considered to be a cause. Indeed, recent evidence indicates that bacteria-derived extracellular vesicles (EV) appear to be an important causative agent of inflammatory diseases. Here, we ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12374
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The importance and specific role(s) of eosinophils in modulating the immune/inflammatory phenotype of allergic pulmonary disease remain to be defined. Established animal models assessing the role(s) of eosinophils as contributors and/or causative agents of disease have relied on congenitally deficient mice w...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12321
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:IL-33 enhances FcεRI-induced mediator release in human basophils without inducing degranulation itself. In contrast, studies in mice suggested that in the presence of high IgE levels, IL-33 triggers degranulation and anaphylaxis of similar severity as specific allergen. Consistent with this view, sera of ato...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12309
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Birch pollen allergies are frequently associated with adverse reactions to various fruits, nuts, or vegetables, described as pollen-food syndrome (PFS) and caused by cross-reactive IgE antibodies primarily directed against Bet v 1. Specific immunotherapy (SIT) represents an effective treatment for inhalant a...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12306
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Immunoglobulin (Ig) A represents a first-line defence mechanism in the airways, but little is known regarding its implication in upper airway disorders. This study aimed to address the hypothesis that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could be impaired in chronic upper airway disea...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12274
更新日期:2013-12-01 00:00:00
abstract::During the last few years, an impressive amount of experimental studies and clinical trials have dealt with a variety of distinct topics in allergic skin diseases - especially atopic dermatitis. In this update, we discuss selected recent data that provide relevant insights into clinical and pathophysiological aspects ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12324
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Anaphylaxis is an acute, potentially fatal, multi-organ system, allergic reaction caused by the release of chemical mediators from mast cells and basophils. Uncertainty exists around epidemiological measures of incidence and prevalence, risk factors, risk of recurrence, and death due to anaphylaxis. This sys...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12272
更新日期:2013-11-01 00:00:00
abstract::The purpose of this study was to investigate whether uncontrolled asthma was associated with healthcare outcomes among Latin American patients with asthma. We used data from 2168 patients with asthma who participated in the 2011 Latin America Asthma Insights and Management (AIM) survey. Using Global Initiative for Ast...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12237
更新日期:2013-11-01 00:00:00
abstract::Overproduction of periostin, an IL-13-inducible matricellular protein, despite corticosteroid treatment is thought to be involved in the chronicity of allergic inflammation seen in corticosteroid-refractory tissue fibrosis. Therefore, we hypothesized that some tissue cells must produce periostin in a corticosteroid-in...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12240
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Allergy diagnosis by determination of allergen-specific IgE is complicated by clinically irrelevant IgE, of which the most prominent example is IgE against cross-reactive carbohydrate determinants (CCDs) that occur on allergens from plants and insects. Therefore, CCDs cause numerous false-positive results. I...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12229
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Recurrent angioedema (RecA) is a frequent clinical problem characterized by suddenly occurring cutaneous and/or mucosal swellings. Depending on their location, RecA may be painful, hindering, disfiguring, or even life-threatening. The assessment of disease activity in affected patients is important to guide ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12209
更新日期:2013-09-01 00:00:00
abstract::Atopic eczema (AE) is a challenge for modern medicine, because it is prevalent, severely affects quality of life of patients and their families, and causes high socioeconomic costs. The pathogenesis of AE is complex. While initial studies suggested a Th2 deviation as primary reason for the disease, numerous studies ad...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12184
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. METHODS:In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12190
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Cold contact urticaria (CCU) is characterized by itchy wheal and flare responses due to the release of histamine and other pro-inflammatory mediators after exposure to cold. The treatment of choice is nonsedating antihistamines, dosages of which may be increased up to fourfold if standard doses are ineffecti...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/all.12171
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Recent studies have yielded heterogeneous results regarding the relationship between vitamin D and atopic conditions. The aim of this study was to investigate the association between serum vitamin D level and the prevalence of eczema in German children and adolescents. METHODS:Data were drawn for children a...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12167
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Exposure to environmental endocrine-disrupting chemicals (EDCs) is associated with allergy, chronic inflammation, and immunodeficiency. Phthalates, the common EDCs used in plastic industry, may act as adjuvants to disrupt immune system and enhance allergy. Plasmacytoid DCs (pDCs) are predominant cells secret...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12162
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Although atopic sensitization is one of the strongest risk factors for asthma, its relationship with asthma is poorly understood. We hypothesize that 'atopy' encompasses multiple sub-phenotypes that relate to asthma in different ways. METHODS:In two population-based birth cohorts (Manchester and Isle of Wig...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12134
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Recombinant allergens offer a tool for improving specific immunotherapy (SIT). OBJECTIVE:To find the optimal dose of a new hypoallergenic folding variant of recombinant Bet v 1 (rBet v 1-FV) as SIT for patients with birch pollen allergy. METHODS:Before SIT, thirty-seven adult patients were exposed for eigh...
journal_title:Allergy
pub_type: 杂志文章,随机对照试验
doi:10.1111/all.12148
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:It is commonly acknowledged that asthma is exacerbated by viral infections. On the other hand, basophil infiltration of lung tissues has been evidenced postmortem in cases of fatal disease, raising the question of a possible link between these two observations. OBJECTIVES:Herein, we addressed the relationsh...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12151
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Asthma and obesity are chronic multifactorial conditions that are associated with gene-environment interaction and immune function. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control. OBJECTIVE:To investigate the impact that weight c...
journal_title:Allergy
pub_type: 杂志文章,meta分析
doi:10.1111/all.12106
更新日期:2013-04-01 00:00:00
abstract::Mast cell activation (MCA) occurs in a number of different clinical conditions, including IgE-dependent allergies, other inflammatory reactions, and mastocytosis. MCA-related symptoms may be mild, moderate, severe, or even life-threatening. The severity of MCA depends on a number of different factors, including geneti...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12126
更新日期:2013-04-01 00:00:00
abstract::The efficacy of single-allergen-specific immunotherapy in polysensitized subjects is a matter of debate. We therefore performed a post hoc analysis of pooled data from six randomized, double-blind, placebo-controlled trials (N = 1871) comparing the efficacy and safety of the SQ-standardized grass allergy immunotherapy...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12074
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Reasons for asthma hospitalizations are dynamic and complex. Comorbid conditions are important contributors to most chronic diseases today. We aim to characterize and describe risk factors associated with hospitalizations due to asthma in the Languedoc-Roussillon region (France) in 2009. METHODS:Programme d...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12137
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The precise immunological mechanisms for the early clinical protection of venom immunotherapy (VIT) have not yet been explained. Our aim was to evaluate whether high-affinity IgE receptor (FcεRI) and the related basophil function have a role in the induction of short-term VIT protection. METHODS:We included...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12044
更新日期:2012-12-01 00:00:00
abstract::Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosano...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12010
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Recent evidence indicates that Staphylococcus aureus, one of the most important human pathogens, secretes vesicles into the extracellular milieu. OBJECTIVE:To evaluate whether inhalation of S. aureus-derived extracellular vesicles (EV) is causally related to the pathogenesis of inflammatory pulmonary diseas...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12001
更新日期:2012-10-01 00:00:00
abstract::Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL-33 receptor. IL-33 receptor is a heterodimer of IL-1 receptor-like 1 (IL-1RL1; also called ST2, T1, Der4, an...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12004
更新日期:2012-10-01 00:00:00
abstract::A one-day intensive educational course on allergy and immunology theory and diagnostic procedure significantly increased the competency of allergy and immunology fellows-in-training. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02869.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway inflammation is unknown. OBJECTIVES:This study investigated whether allergen-induced airway inflammation involves an impaired local AM response. METHO...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02851.x
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Pollutants may affect pollen allergenicity and thus the prevalence of allergies. Although a few studies are available in literature, the connection between pollution and the allergenic potential of pollen has yet to be clearly defined. The objective of this study was to evaluate the effect of traffic-related...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02846.x
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Undernotification is well recognized as a key challenge to the study of anaphylaxis mortality, but it is seldom mentioned that one of its reasons is the difficult coding of the condition under the tenth revision of the international classification of diseases (ICD-10), given that there are no anaphylaxis-spe...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02829.x
更新日期:2012-06-01 00:00:00
abstract::The leading priority for the Polish Presidency of the Council of the European Union was to reduce health inequalities across European societies, and, within its framework, prevention and control of respiratory diseases in children. This very important paper contain proposal of international cooperation on the preventi...
journal_title:Allergy
pub_type: 共识发展会议,杂志文章,评审
doi:10.1111/j.1398-9995.2012.02822.x
更新日期:2012-06-01 00:00:00
abstract::Monozygotic (MZ) twins discordant for complex diseases may help to find disease mechanisms that are not due to genetic variants. Intermittent allergic rhinitis (IAR) is an optimal disease model because it occurs at defined time points each year, owing to known external antigens. We hypothesized that MZ twins discordan...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2012.02828.x
更新日期:2012-06-01 00:00:00